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卢昱竹1 吴家如2 洪崧壬3 林荣兴2 陈中奎1
谢明颖1 蔡婉婷4 何宗融1,4,5* 陈灏平2,6*
1 佛教慈济医院财团法人花莲慈济医院中医部，花莲，台湾
2 佛教慈济医院财团法人花莲慈济医院中西医合疗中心，花莲，台湾
3 佛教慈济医院财团法人花莲慈济医院皮肤科，花莲，台湾
4 佛教慈济医院财团法人花莲慈济医院院长室，花莲，台湾
5 慈济大学学士後中医学系，花莲，台湾
6 慈济大学医学系生物化学学科，花莲，台湾
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目的：烧烫伤的中医外用制剂，常使用大黄、黄连、黄檗等清热解毒药，来治疗烧烫伤後的伤口。本实验以治疗烧烫伤的西药『烫肤舒』为对照组，比较大黄、黄连、黄檗组成的『三黄散』对浅二度烫伤的治疗效果。
方法：由於猪只的体型大小与皮肤结构，皆与人类最为接近，故选择猪只为实验动物。伤口愈合的过程中，在第7、14、21 天以照相记录伤口外观，同时将组织切片以苏木精－伊红染色（Hematoxylin and Eosin stain；以下简称H&E）、马森三色染色（Masson’s trichrome stain；以下简称MT）和免疫组织化学染色（Immunohistochemistry；以下简称IHC），比较『三黄散』与烫肤舒对烫伤伤口愈合的差异。
结果：在伤口愈合过程的组织病理学评估，三黄散对於皮下组织的纤维母细胞增殖和胶原蛋白合成、血管新生的表现皆优於烫肤舒对照组。动物实验的结果显示，没有任何实验动物出现感染症状。
结论：本研究结果显示了『三黄散』对浅二度烫伤疗效，并对将来改进传统中药制剂『三黄散』提供了基础。
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Yu-Chu Lu1Jia-Ru Wu2Sung-Jen Hung3Jung-Hsing Lin2Jhong-Kuei Chen1
Ming-Ying Hsieh1Wan-Ting Tsai4Tsung-Jung Ho1,4,5*Hao-Ping Chen2,6*
1Department of Chinese Medicine, Hualien Tzu Chi Hospital, Hualien, Taiwan
2Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital,
Hualien, Taiwan
3Department of Dermatology, Hualien Tzu Chi Hospital, Hualien, Taiwan
4Department of Superintendent Office, Hualien Tzu Chi Hospital, Hualien, Taiwan
5Department of Biochemistry, Tzu Chi University, Hualien, Taiwan
6School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan
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Objectives: "San Huang Powder" is frequently used for the treatment of burn wounds in traditional Chinese medicine. It was prepared from the following three yellow-colored herbs: Rhubarb, Phellodendron bark, and Coptidis rhizome in this study.
Methods: Because the pig’s size and skin composition are the closest to the human body, the pig was employed as the experimental animal. Western medicine,Siliverzine cream, was used as the control. Histopathological evaluation, including MT staining, H&E staining, and IHC staining, of dermal tissue healing, was carried out to compare the efficacy of "San Huang Powder" and the control after surgery on day 7, 14, and 21.
Results: In the histopathological evaluation of the wound healing process, San Huang Powder is better than Siliverzine cream in terms of fibroblast proliferation,collagen synthesis and angiogenesis in the subcutaneous tissue. The results of animal experiments showed that no wound infection was observed in all experimental animals.
Conclusions: The results of this study show the efficacy of "San Huang Powder" on superficial second-degree scalds and provide the basis to improve the preparation of this traditional medicine.
【Keywords】Burn Wound; Rhubarb; San Huang Powder; Silver Sulfadiazine Cream; Wound Healing
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241.2 中药『三黄散』对烫伤的疗效研究
