|
前言：忧郁及冷漠是失智症患者常见精神症状，尤以寒冷且光照较少的冬天更易出现。本研究探讨并用麻黄附子细辛汤与智爱汤，对於失智症患者在冬季时的忧郁及冷漠等症状的疗效。
方法：招募2014 年11 月至2015 年3 月间，因失智症伴有明显忧郁或冷漠，而希望接受中医治疗的患者，用追踪观察法研究26 名自愿叁与者的精神与神经学症状进展。试验前四周每位患者接受每日早晨服用中药智爱汤一包（100ml），及一日两次每次4 克麻黄附子细辛汤浓缩中药粉剂。治疗後八周我们继续使用智爱汤作维持治疗，疗效指标包含简短版神经精神量表（NPI-Q）、简易心智量表（MMSE）、工具性日常生活活动能力量表（IADL）与日常生活活动功能量表（ADL）。测量时间为治疗开始前与治疗後各作一次测量。
结果：研究结束时共有24 位叁与者完成研究，叁与者的NPI-Q 总分及忧郁、冷漠两项分数明显下降且达统计意义，ADL 与IADL 分数均显着上升且达统计意义。在两个月後续维持治疗时，IADL、MMSE、NPI-Q总分与治疗前差异不明显，显示治疗效果在两个月内能继续维持。
结论：本研究发现服用智爱汤合并麻黄附子细辛汤可减缓失智症患者的忧郁及冷漠症状，并能改善日常活动能力，但对於认知能力无显着影响，建议未来可在失智症临床照护上推广使用。
|
|
Mei-Ru Chen1 Yu-Ling Huang1 Hsu-Tung Hsieh1 Su-Jhen Wu2
Shun-Ku Lin1*
1Department of Chinese Medicine, Taipei City Hospital, Ren-Ai Branch . Department of
Health, Taipei City Government
2Department of Pharmacy, Taipei City Hospital, Ren-Ai Branch . Department of Health,
Taipei City Government
|
|
Background: Depression and indifference are common psychiatric symptoms in people with dementia, especially in the cold and less sunny days are more likely to occur. This study explored the effects of combined use of Ma-Huang-Fu-Zi-Xi-Xin-Tang and Zhi-Ai-Tang on mental and behavioral symptoms such as depression and indifference during dementia in winter.
Methods: We recruited patients with dementia associated with marked depression or indifference from November 2014 to March 2015, who were expecting to receive Chinese medicine treatment. The follow-up observation was used to study the status of medication and symptom progression in 26 volunteers. During the experiment, each patient received a package（100ml）of traditional Chinese medicine, Zhi-Ai-Tang, every morning, and four grams of Ma-Huang-Fu-Zi-Xi-Xin-Tang powder for four consecutive weeks. After treatment, we continued to use Chi Ai Tang for two months of maintenance therapy; curative effect indicators include a short version of neuropsychiatric scale（NPI-Q）, simple mental scale （MMSE）, instrumental activities of daily living scale IADL）and daily life function scale（ADL）. We Measured before and after the three-month treatment.
Results: At the end of the study, a total of 24 participants completed the study, the participants of the NPI-Q score and depression, apathy two scores decreased significantly and statistical significance, ADL and IADL scores were significantly increased and reached statistical significance. In two months follow-up maintenance therapy, IADL、MMSE、NPI-Q score and the difference between the treatment is not apparent, showing that treatment can continue to maintain within two months.
Conclusions: The study found that taking traditional Chinese medicine Ma-Huang-Fu-Zi-Xi-Xin-Tang and Zhi-Ai-Tang could slow dementia patients with depression and apathy symptoms and can improve the ability of daily activities,but no significant impact on cognitive ability, it is recommended to the future clinical dementia Care to promote the use.
Keywords： Dementia, depression, indifference, Ma-Huang-Fu-Zi-Xi-Xin-Tang, Zhi-Ai-Tang
|
201.2麻黄附子细辛汤与智爱汤治疗失智患者冬季忧郁及冷漠症状
