Objectives: Eczema is a common skin condition triggered by genetic, environmental, dietary factors, and bacterial infections, characterized by dry skin, itching, scratching, scaling, and crusting. It often recurs, impacting quality of life. While corticosteroids are effective treatments in Western medicine, long-term use may lead to side effects. Traditional Chinese medicine (TCM) employs herbs to dispel pathogenic wind, eliminate dampness, and clear heat-toxin, which are effective but require lengthy preparation, resulting in low compliance. Therefore, developing a herbal cream formulation for eczema treatment shows promise. Methods: This study recruited 35 eczema patients and utilized the TCM prescription "Kushen Decoction", combined with local herbs such as Plectranthus amboinicus and Salvia plebeia, to create a topical cream. Patients applied the cream twice daily for twelve weeks, with six follow-up visits for assessments. Evaluation metrics included the Dermatology Life Quality Index (DLQI), SCORing Atopic Dermatitis (SCORAD), and Eczema Area and Severity Index (EASI). Results: Significant improvements were observed in DLQI, SCORAD, and EASI scores post-treatment (p<0.001). Specifically, DLQI decreased from 18.17 to 6.49, SCORAD from 40.90 to 12.51, and EASI from 4.97 to 1.46. These results indicate that the improved herbal cream formulation is not only effective in treating eczema but also enhances patients’ quality of life. Conclusion: This study confirms the efficacy of the herbal cream formulation for eczema treatment, offering moisturizing benefits and convenience, thus providing a new therapeutic option for patients. Future research targeting severe eczema patients will further validate the effectiveness of TCM interventions.
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291-1 中草药乳霜对湿疹患者的疗效评估 及生活品质改善之研究
