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中医药研究论丛
 231.10 中草药转骨之近代研究进展
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TJ TCM.23(1) : 119-136, 2020
DOI : 10.6516/TJTCM.202003_23(1).0010
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中草药转骨之近代研究进展
Development of Recent Research on the Tńg-Kut Herbal Medicine
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陈冠佐1,2,4 林琬羚3 游雅晴1 蔡金川1,2,4*
1 义大癌治疗医院中医科，高雄，台湾
2 义大医院中医部，高雄，台湾
3 高雄荣民总医院中医部，高雄，台湾
4 义守大学学士後中医学系，高雄，台湾
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【摘要】
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转骨方剂包含传统中药与在地草药，应用於促进青春期间的生长发育，为台湾特有经验。本文之目的将探讨青春期的骨骼变化与转骨中草药之药理作用、以供临床上的应用。青春期的骨骼改变包含纵向骨生长与骨矿获取，其高峰发生时间先後依序为纵向生长高峰与骨矿获取高峰。生理改变以谭纳阶段（Tanner stage，T）作评估比年龄时间轴更为恰当。青春期时生长突增期男性约於起始於T2，於T3-4 达到生长高峰；女性同样起始於T2，在T2-3 达到生长高峰。据研究显示杜仲、砂仁、竹茹与方剂Jaoga-Yukmiwon(R)、HT042、Bojungikgitang-gagambang 具有促进骨纵向生长效果，这类中草药适合於T2 开始使用。无论是男性或女性，约25% 的骨质於骨矿获取高峰期邻近2 年内累积，男性约於T3-5，女性於T2-4 之间。男性骨矿获取高峰期约接近T4，女性骨矿获取高峰约於T3-4，接近初经来潮时期。促进骨获取的中草药包含杜仲、续断、红花、肉苁蓉、冬虫夏草、女贞子、补碎骨、补骨脂、巴戟天、地黄、九层塔与蚶壳草。以中医而言，这些中草药大部分具有补益肝肾效果。精准用药时期男性约於T3-5，女性於T2-4 之间。
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【关键词】骨纵向生长、中药、草药
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Kuan-Tso Chen1,2,4Wan-Ling Lin3Ya-Ching Yu1Chin-Chuan Tsai1,2,4*
1The Department of Chinese Medicine of E-DA Cancer Hospital, Kaohsiung, Taiwan
2The Department of Chinese Medicine of E-DA Hospital, Kaohsiung, Taiwan
3Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
4The School of Chinese Medicine for Post-Baccalaureate of I-Shou University, Kaohsiung, Taiwan
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【Summary】
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The Tńg-Kut decoctions, applied for adelocence to promote physical growth and development during puberty, were composed of traditional Chinese medicines and native folk herbs, which is regarded as a widespread unique experience used in Taiwan. The objective of this review article is to investigate the clinical indication and pharmacological effects of the Tńg-Kut decoctions. The skeletal development consist of longitudinal change in linear growth and bone mineral gain during puberty. Physiological growth is more accurately evaluated by using Tanner Stages than by chronological age alone. Girls tend to get growth spurt at Tanner stage 2 and achieve peak height velocity during Tanner stage 2-3. The pubertal growth spurt in Boys begins at Tanner stage 2 and the peak height velocity occur during Tanner stage 3-4. Eucommia ulmoides, Amomum villosum, Phyllostachyos Caulis and the 3 dectoctions- Jaoga-Yukmiwon (R), HT042, Bojungikgitang-gagambang were recognized to have pharmacological effect to induce longitudinal bone growth, and the appropriate time for those herbal intervention in both adolescent Boys and Girls is after the onset of Tanner stage 2. It is estimated that one quarter of adult bone mass is accumulated in the two years surrounding peak bone mineral content velocity, which corresponds to Tanner stage 2-4 in girls and Tanner stage 3-5 in Boys.The peak bone mineral content velocity occurred at Tanner stage 4 in Boys, and at Tanner stage 3-4 in Girls coincided closely with the period at menarche. Eucommia ulmoides, Dipsacus asper, Carthamus tinctorius, Cistanche deserticola, Cordyceps sinensis, Drynaria fortune, Ligustrum lucidum, Morinda officinalis,Psoralea corylifolia, Rehmannia glutinosa, Ocimum basilicum, Centella asiatica were confirmed to possess the bone accural activicity. Most of these herbs were regarded as liver- and kidney-tonic herbs, and which were precisely for adolescent Boys between Tanner stage 3-5 and for Girls in Tanner stage 2-4.
Keywords： longitudinal bone growth, traditional Chinese medicine, herb
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