中医药研究论丛

201.7肝炎常用中药之现代药理机转文献回顾

 

肝炎常用中药之现代药理机转文献回顾
A Review of Chinese Herbal Medicines Used for Hepatitis
严如庆1 蔡金川1,2*
1 义守大学学士後中医学系,高雄,台湾
2 义大医疗财团法人义大医院中医部,高雄,台湾
【摘要】
台湾的肝炎盛行率非常高,肝炎造成的伤害会变成肝纤维化,而导致肝硬化,中药常用来治疗肝病,因此找寻有效的成分是中医药研究的方向,利用天然药物学、分子生物学的技术,希望能够从天然药物中筛选出有效的抗肝炎成分。本文探讨常见肝炎治病的中西医病因,并回顾文献探讨临床常用治疗肝炎中药之机转,发现丹叁、黄耆、大黄、黄芩等药物,可以抗肝炎病毒,透过不同的机转来抑制病毒,如:抑制病毒的复制、控制细胞凋亡、提升免疫力来达到疗效,有些药物尚有改善肝功能、抗肝纤维化等功效。
【关键词】
肝炎、中药
 
Ju-Ching Yen1 Chin-Chuan Tsai1,2*
1The School of Chinese medicine for Post Baccalaureate of I-Shou University, Kaohsiung, Taiwan
2The Department of Chinese medicine of E-DA Hospital, Kaohsiung, Taiwan
【Summary】
Taiwan have very high rates of hepatitis and the inflammation and damage can cause fibrosis, which eventually can lead to cirrhosis. Traditional Chinese medicine is commonly used in treating liver diseases. It is important that the challenge to find effective components in traditional chinese medical. By using the technology of natural medicine and molecular biology, the ingredients of natural medicine can be selected in curing heptitis. In this paper, we discuss the common causes of hepatitis treatment in Western and Chinese medicine. Also,we review several research papers about mechanisms of Chinese herbal medicines used in treatment of hepatitis, such as Salvia, Astragalus, rhubarb and skullcap. All of them can be anti-hepatitis virus by different mechanisms to inhibit viral transfer, such as inhibition of viral replication, control apoptosis, boost the immune system to achieve a therapeutic effect,and individually may have the effects of improving liver function, hepatic fibrosis for treating heptitis.
KeywordsHepatitis, traditional Chinese medicine