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During the cancer therapy, the appearance of supra vena cava syndrome (SVCS) often leads to poor prognosis. The use of blood-activating drugs in traditional Chinese medicine can help the establishment of the collateral circulation of the superior vena cava which can relieve the clinical symptoms.
Patients are able to gain more time to analyze tumor cell type which timely accepted chemotherapy, radiation therapy or surgery. Scholars generally worry about blood-activating drugs will enhance the angiogenesis of tumor cells which may concern its safety. So we analysis the literature which indicates that bloodactivating drugs do have the ability to increase tumor cell angiogenesis, but more over it can establish effective perfusion, in addition to improving local anoxic status of tumor cells. The reduction of hypoxia-induced factor (HIF), which leads to the decrease of vascular endothelial growth factor (VEGF) production. Due to blood-activating drugs established effective perfusion, chemical drugs can poison the tumor cell more directly.
To sum up, the superior vena cava syndrome is a urgent clinical complication during cancer therapy. The patients with supra vena cava syndrome can take blood-activating drugs to relieve the symptoms of clinical discomfort, also gain more time to obtain anticancer therapy.
Keywords：supra vena cava syndrome, SVCS, blood-activating drugs, Chinese medicine combine care
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231.6 活血法运用在肿瘤造成之上腔静脉症候群之文献回顾
